Real-World Clinical and Economic Outcomes Among Patients with Localized Prostate Cancer Undergoing Radical...

Area of Science:

• Urology
• Oncology
• Health Economics

Background:

• Radical prostatectomy (RP) offers curative potential for localized prostate cancer (LPC).
• Limited data exist on clinical and economic outcomes stratified by LPC risk group post-RP.
• This study addresses the need for comprehensive outcome data in routine US urology practice.

Purpose of the Study:

• To compare survival and healthcare costs after RP in high-risk LPC versus low/intermediate-risk LPC patients.
• To evaluate the real-world clinical and economic impact of LPC risk stratification following RP.

Main Methods:

• Utilized linked electronic medical records and administrative claims data.
• Classified patients into high-risk and low/intermediate-risk LPC cohorts based on NCCN® guidelines.
• Employed inverse probability of treatment weighting for cohort balancing and Cox models/OLS regression for survival and cost comparisons.

Main Results:

• High-risk LPC patients exhibited significantly higher rates of metastasis and disease progression post-RP.
• The high-risk cohort incurred substantially greater mean total all-cause and PC-related healthcare costs.
• Statistical significance was maintained across all survival and cost outcome comparisons (p<0.001).

Conclusions:

• High-risk LPC following radical prostatectomy is associated with poorer survival outcomes.
• Elevated healthcare costs are significantly linked to high-risk LPC post-procedure.
• Findings underscore the substantial clinical and economic burden of high-risk localized prostate cancer.