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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

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Updated: Jun 3, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Nanoparticle-Based Drug Delivery Systems: Emerging Strategies and Future Perspectives.

Meenakshi Dhanawat1, Garima2, Pramila Chaubey3

  • 1Amity Institute of Pharmacy, Amity University Haryana, Gurugram-122413, India.

Current Drug Delivery
|June 2, 2026
PubMed
Summary
This summary is machine-generated.

Nanoparticle drug delivery systems overcome traditional limitations, enhancing bioavailability and reducing toxicity. Innovations like stimuli-responsive and theranostic platforms enable personalized therapies with improved targeting and monitoring.

Keywords:
Nanomaterialsdrug targetingmultifunctional nanoplatformsnano-drug deliverynatural productspersonalized medicinesmart drug delivery systems.stimuli-responsive nanoparticles

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Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmacology

Background:

  • Traditional drug delivery faces challenges like poor transport, short circulation, instability, and toxicity.
  • Nanoparticles offer solutions by enhancing bioavailability and reducing off-target effects via targeted delivery and controlled release.

Purpose of the Study:

  • To review advancements in nanoparticle-based drug delivery systems.
  • To provide guidance for developing next-generation platforms with clinical relevance.

Main Methods:

  • Review of current literature on various nanocarriers.
  • Analysis of innovative approaches such as stimuli-responsive and theranostic platforms.

Main Results:

  • Diverse nanocarriers (polymeric, liposomes, metallic, etc.) enable spatiotemporal drug release.
  • Emerging technologies like theranostics integrate diagnostics and therapy for personalized medicine.

Conclusions:

  • Nanoparticle drug delivery significantly improves therapeutic efficacy and patient outcomes.
  • Future directions focus on intelligent, multifunctional systems for enhanced clinical application.