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Updated: Jun 3, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Endovascular Treatment Versus Medical Management in Patients with Large Vessel Occlusion and Pre-Stroke Disability: A
Aim:
To assess the effectiveness and safety of endovascular treatment (EVT) versus medical management (MM) in stroke patients with premorbid disabilities.
Material And Methods:
A systematic search was conducted in PubMed, Embase, and the Cochrane Library for studies on EVT in large vessel occlusion (LVO) patients with pre-stroke modified Rankin Scale (mRS) score of 2-4. The primary outcome was functional recovery, defined as returning to at least the pre-stroke mRS score within 90 days. The secondary outcomes included symptomatic intracranial hemorrhage (sICH) and 90-day mortality. The meta-analyses were conducted via random effects models.
Results:
Six cohort studies involving 2,106 patients were included. Compared with MM, EVT was associated with a higher likelihood of functional recovery (adjusted odds ratio [aOR], 3.26; 95% confidence interval [CI], 2.26-4.70; p.
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