Related Experiment Video
Updated: Jun 3, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Immune interventions in stroke: current progress and perspectives
Cunle Guo1, Di Guan2,3, Qiang Liu4
1Department of Neurology, Tianjin Neurological Institute, Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, International Joint Laboratory of Ocular Diseases, Ministry of Education, Haihe Laboratory of Cell Ecosystem, Laboratory of Post-Neuroinjury Neurorepair and Regeneration in Central Nervous System Tianjin & Ministry of Education, Tianjin Medical University General Hospital, Tianjin, 300052, China.
This review explores neuroimmune interventions for acute ischemic stroke (AIS), detailing immune cell roles and therapeutic strategies. It highlights progress and challenges in developing precision immune therapies for stroke treatment.
Area of Science:
- Neuroscience
- Immunology
- Cerebrovascular Medicine
Background:
- Acute ischemic stroke (AIS) causes significant disability and mortality.
- Neuroinflammation is a key factor in secondary brain injury after AIS.
- Understanding immune cell roles is crucial for developing effective treatments.
Purpose of the Study:
- To review recent advances in neuroimmune interventions for AIS.
- To analyze the mechanisms and clinical progress of various immune-modulating therapies.
- To identify challenges and future directions for precision immune therapy in AIS.
Main Methods:
- Systematic literature review of PubMed, Web of Science, Embase, and Ovid Medicine.
- Analysis of immune cell functions (microglia, astrocytes, T cells, etc.) in the ischemic brain.
- Summary of clinical research on therapeutic agents and cell transplantation.
Main Results:
- Detailed mechanisms of pro- and anti-inflammatory immune cells in AIS.
- Overview of clinical efficacy, safety, and mechanisms of agents like tirofiban, methylprednisolone, and JAK inhibitors.
- Assessment of cell transplantation therapies and their potential.
Conclusions:
- Neuroinflammation plays a complex role in AIS, offering therapeutic targets.
- Several promising immune-modulating agents are under investigation.
- Challenges in clinical translation include targeting efficiency and safety, necessitating precision medicine approaches.
Related Concept Videos
Ischemic Stroke ll: Pathophysiology
Venous Thrombosis III: Interprofessional Care
Ischemic Stroke l: Introduction
Acute Coronary Syndrome IV: Interprofessional Care
Hemorrhagic Stroke ll: Pathophysiology
Hemorrhagic Stroke l: Introduction