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PANCS-spec-Binders: A system for rapidly discovering isoform- or epitope-specific binders

Joshua A Pixley1, Matthew J Styles1, Kanokpol Aphicho1

  • 1Department of Chemistry, University of Chicago, Chicago, IL 60637.

Proceedings of the National Academy of Sciences of the United States of America
|June 2, 2026
PubMed
Summary

We developed PANCS-spec-Binders, a new method for discovering specific protein binders. This technique uses selection and counterselection to rapidly identify binders with high specificity for therapeutic and research applications.

Keywords:
binder discoverybiotechnologydirected evolutionhot spotsprotein-protein interaction (PPI)

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