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Identification of the Novel HLA-DPB1*1493:01:01:01 Allele Using Nanopore Sequencing Technology

Nanying Chen1, Wenwen Pi1, Chen Chen1

  • 1HLA Typing Laboratory, Blood Center of Zhejiang Province, Hangzhou, China.

HLA
|June 2, 2026
PubMed

Abstract:

HLA-DPB1*1493:01:01:01 differs from HLA-DPB1*547:01 by one single nucleotide substitution at position 292 G>A in exon 2.

Keywords:
HLA‐DPB1*1493:01:01:01nanopore sequencingnovel allele

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

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