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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

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Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
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Irritable Bowel Syndrome III: Medical and Nursing Management

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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...

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Related Experiment Videos

Refractory/therapy-resistant/intractable constipation in children.

Carlos Alberto Velasco-Benítez1, Wilson Daza Carreño2, Michelle Higuera Carrillo3

  • 1Hospital Universitario del Valle, Universidad del Valle, Cali, Valle del Cauca, Colombia.

BMJ Paediatrics Open
|June 2, 2026
PubMed
Summary
This summary is machine-generated.

Paediatric gastroenterologists prefer "refractory constipation" over "intractable constipation." This new definition emphasizes symptom persistence despite optimal treatment for 2-3 months after excluding organic causes.

Keywords:
ChildrenGastroenterology

Related Experiment Videos

Area of Science:

  • Pediatric Gastroenterology
  • Clinical Practice Guidelines
  • Constipation Management

Background:

  • Intractable constipation (IC) requires clearer definition for accurate characterization.
  • Understanding current definitions used by Latin and Ibero-American paediatric gastroenterologists is crucial.

Purpose of the Study:

  • To determine how paediatric gastroenterologists in Latin America and Ibero-America define intractable constipation.
  • To explore preferences for a unified terminology for intractable constipation.

Main Methods:

  • A questionnaire survey was administered to 429 paediatric gastroenterologists.
  • Data were analyzed using univariate and bivariate statistics, including odds ratios (ORs) and 95% confidence intervals (CIs).

Main Results:

  • Most respondents (94.6%) defined IC by persistent low bowel frequency despite optimal medical treatment (OMT).
  • Prior treatment failure was commonly defined as using two laxatives (51.7%).
  • A majority preferred the term 'refractory constipation' (86.7%) and to include 'optimal medical treatment' in diagnostic criteria (93.0%).

Conclusions:

  • Paediatric gastroenterologists in Latin and Ibero-America favor replacing 'intractable constipation' with 'refractory constipation' or 'treatment-resistant constipation'.
  • The proposed definition involves persistent symptoms despite 2-3 months of appropriately prescribed, supervised, and adhered-to optimal conventional medical treatment, after excluding organic causes.