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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
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Biofunctional Surface Modification of Polymeric Implants for Biomedical Applications.

Ritika Tripathi1, M Sudhakara Reddy2, Suchitra Rajput1

  • 1Centre for Advanced Materials and Devices (CAMD), School of Engineering and Technology, BML Munjal University, Gurgaon, Haryana, India.

Macromolecular Rapid Communications
|June 2, 2026
PubMed
Summary
This summary is machine-generated.

Surface modification of polymers is crucial for biomedical implants to improve biocompatibility and function. This review covers strategies to enhance polymer interfaces for better cell adhesion and reduced bacterial colonization.

Keywords:
antibacterial coatingantifouling coatingbiofilm inhibitionbiofoulingcoatingimplant coatingmaterials sciencesurface modification

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surface Engineering

Background:

  • The polymer-biological interface is critical for implant success, influencing protein adsorption, cell adhesion, and bacterial colonization.
  • Pristine polymer surfaces in biomedical implants face challenges interacting with physiological environments, impacting long-term biocompatibility.
  • Surface modification is essential to tailor polymer interfaces for optimal biological and functional performance.

Purpose of the Study:

  • To provide a comprehensive review of polymeric materials used in biomedical implants.
  • To discuss surface modification strategies for enhancing polymer performance in biomedical applications.
  • To highlight approaches for improving hydrophilicity, mechanical integrity, and bioactivity, while adding antibacterial and antifouling properties.

Main Methods:

  • Literature review of biodegradable and non-biodegradable polymers in biomedical implants.
  • Analysis of surface modification techniques to improve polymer-biological interactions.
  • Synthesis of information on strategies imparting specific biological properties (antibacterial, antifouling, antithrombogenic).

Main Results:

  • Various surface modification strategies can significantly enhance polymer performance in biomedical implants.
  • Tailoring surface properties like hydrophilicity and mechanical integrity improves interfacial bioactivity.
  • Imparting antibacterial, antifouling, and antithrombogenic properties is achievable through specific surface modifications.

Conclusions:

  • Effective surface engineering of polymers is key to overcoming challenges in biomedical implant applications.
  • Surface modification strategies offer pathways to optimize biocompatibility and functional performance of polymeric implants.
  • Further research into advanced surface modifications will continue to improve the efficacy and longevity of biomedical implants.