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Epstein-Barr Virus Entry: An Updated Review.

Ting Zhang1, Zhuo-Qi Li1, De Pang1

  • 1Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, Guangdong, China.

Journal of Medical Virology
|June 3, 2026
PubMed
Summary
This summary is machine-generated.

Epstein-Barr virus (EBV) causes significant malignancies by infecting B cells and epithelial cells. This review details the viral glycoproteins and host receptors crucial for EBV

Keywords:
B cellsEpstein–Barr virusepithelial cellsreceptorsvirus entry

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Area of Science:

  • Virology
  • Molecular Biology
  • Oncology

Background:

  • Epstein-Barr virus (EBV), a human gamma-herpesvirus, is linked to ~200,000 annual cancer cases.
  • EBV exhibits specific tropism for B cells and epithelial cells.
  • Understanding EBV's cellular interactions is key to combating associated malignancies.

Purpose of the Study:

  • To systematically review the molecular mechanisms of EBV cellular tropism.
  • To summarize identified host cell receptors involved in EBV entry.
  • To provide a comprehensive overview of current EBV infection insights.

Main Methods:

  • Literature review of recent findings on EBV tropism and entry.
  • Systematic summary of identified viral glycoproteins and host receptors.
  • Analysis of molecular interactions governing EBV cellular specificity.

Main Results:

  • Several host cell receptors mediating EBV infection in B cells and epithelial cells have been identified.
  • Key molecular events underlying EBV's distinct cellular tropism are elucidated.
  • The intricate interplay between viral envelope glycoproteins and host receptors is highlighted.

Conclusions:

  • Recent discoveries have significantly advanced the understanding of EBV cellular tropism.
  • Identified host receptors are critical determinants of EBV's infectivity.
  • This review consolidates current knowledge on EBV entry mechanisms.