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Epstein-Barr Virus Entry: An Updated Review
Ting Zhang1, Zhuo-Qi Li1, De Pang1
1Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, Guangdong, China.
None:
Epstein-Barr virus (EBV), a ubiquitous human gamma-herpesvirus, causes approximately 200,000 new malignancies annually, including B-cell lymphomas and epithelial carcinomas. EBV displays distinct host tropism for B cells and epithelial cells, driven by intricate interactions between viral envelope glycoproteins and cell-type-specific receptors. Recently, several host cell receptors mediating EBV infection of B cells and epithelial cells have been identified. This review systematically summarizes the key molecular events underlying EBV cellular tropism and entry, offering a comprehensive overview of current insights into these processes.
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