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Retrospective Analysis of Acute Kidney Injury in  Hospitalizations with Covid-19

Öznur Sarı1, Mehmet Polat2

  • 1Republic of Turkey Ministry of Health Yenimahalle Training and Research Hospital, Department of Internal Medicine, Ankara, Turkey.

Iranian Journal of Kidney Diseases
|June 3, 2026
PubMed

Insights

COVID-19 patients face a high risk of acute kidney injury (AKI), which significantly increases mortality. Hemodialysis in these patients is linked to lower recovery and higher death rates, necessitating further research.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Coronavirus Disease 2019 (COVID-19) poses a global health threat, with significant impacts beyond pulmonary manifestations.
  • Kidney susceptibility to COVID-19 infection can lead to acute kidney injury (AKI), a serious complication.
  • Understanding AKI in COVID-19 is crucial for patient management and outcomes.

Purpose of the Study:

  • To determine the incidence of AKI in hospitalized COVID-19 patients.
  • To characterize the clinical features and outcomes associated with AKI in this population.
  • To evaluate the impact of AKI on mortality and recovery rates among COVID-19 survivors.

Main Methods:

  • Retrospective analysis of medical records from 755 COVID-19 patients with AKI and 4647 without AKI.
  • Data collection included demographics, length of stay, laboratory results, and need for renal replacement therapy.
  • AKI staging was determined using initial and peak renal parameter values.

Main Results:

  • A high incidence of AKI was observed in COVID-19 patients, especially those in intensive care units.
  • Patients with AKI, particularly those requiring hemodialysis (49.32%), exhibited lower recovery (83.84%) and discharge rates.
  • Mortality rates were significantly higher in patients with AKI (P = .032), with 33.64% mortality among those on hemodialysis.

Conclusions:

  • Acute kidney injury (AKI) development in COVID-19 patients is strongly associated with increased mortality risk.
  • The findings highlight the severity of AKI in COVID-19 and the critical need for hemodialysis.
  • Further in-depth research is warranted to elucidate the mechanisms and optimize management strategies for AKI in COVID-19.
Abstract

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