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Related Experiment Video

Updated: Jun 29, 2026

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

lncRNA-mRNA Co-expression Network Unveils Neutrophil Metabolic Reprogramming in Human Sepsis.

Peng Zhang^1,2, Fupeng Wang¹, Kang Zhao³

¹Department of Critical Care Medicine, Department of Transfusion Medicine, Daping Hospital, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University, Chongqing, 400042, China.

|June 3, 2026

Summary

This summary is machine-generated.

Sepsis alters neutrophil metabolism. This study identifies long non-coding RNAs (lncRNAs) regulating amino acid metabolism in neutrophils during sepsis, offering new therapeutic targets.

Keywords:

Metabolism Neutrophil Sepsis lncRNAs

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Published on: November 11, 2025

Area of Science:

Immunology
Molecular Biology
Metabolomics

Background:

Sepsis involves immune dysregulation and metabolic changes in immune cells.
Neutrophils are key players in sepsis, adapting their metabolism for effector functions.
Long non-coding RNAs (lncRNAs) influence sepsis progression and metabolic reprogramming.

Purpose of the Study:

To investigate the interplay between lncRNAs and metabolic reprogramming in neutrophils during sepsis.
To identify specific lncRNAs and metabolic pathways involved in neutrophil dysfunction in sepsis.

Main Methods:

RNA sequencing was performed on neutrophils isolated from septic patients.
Bioinformatic analysis was used to identify differentially expressed genes and lncRNA networks.
Co-expression network analysis was employed to uncover regulatory relationships.

Main Results:

A set of hub differentially expressed genes related to amino acid metabolism was identified in septic neutrophils.
Potential lncRNA networks regulating these metabolic genes were uncovered.
The study revealed a broader landscape of neutrophil metabolic reprogramming in sepsis.

Conclusions:

lncRNAs play a significant role in regulating amino acid metabolism in neutrophils during sepsis.
The findings provide a foundational co-expression network for future research.
This work opens new avenues for understanding and targeting lncRNA-mediated metabolic alterations in sepsis.