Related Experiment Video

Updated: Jun 5, 2026

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

ATAD3A Limits Aortic Dissection via Mito-Lysosome Contacts and Lipoylation

Jie Lin1,2, Shengjun Xiong1,2, Ying An1,2

  • 1Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Shanghai, Zhongshan Hospital, Fudan University, China (J.L., S.X., Y.A., L.W., Y.D., Y.E.L., Y.W., Z.D., J.G., Y.Z., J.R.).

Circulation Research
|June 4, 2026
PubMed
Summary

The mitochondrial protein ATAD3A protects against aortic aneurysm and dissection (AAD) by regulating mitochondrial calcium and cuproptosis in vascular smooth muscle cells. Targeting this ATAD3A-DLST-cuproptosis pathway may offer new therapies for AAD.

Keywords:
aortic aneurysmaortic dissectioncalciumcuproptosismitochondria

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