Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) in a 56-Year-Old Patient With Silicone Breast Implants:...

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is a clinically complex condition triggered in genetically predisposed individuals by substances such as silicone in breast implants. Although silicone implants have traditionally been considered inert, increasing evidence links them to autoimmune phenomena. This report presents a 56-year-old woman who experienced progressive muscle weakness, hand and facial edema, alopecia, and elevated creatine kinase levels one year after silicone implant exchange. A diagnosis of ASIA, complicated by Grade IV capsular contracture, was established based on clinical, serological, and dermatological findings. Despite initial immunosuppressive therapy, symptoms persisted, prompting explantation and mastopexy. This case underscores the value of a multidisciplinary approach and highlights explantation as a potential strategy for improving ASIA-related outcomes.