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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
Personality Disorders: Dependent and Obsessive-Compulsive01:24

Personality Disorders: Dependent and Obsessive-Compulsive

Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
 Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle with...

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Related Experiment Video

Updated: Jun 5, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Obsessive-compulsive disorder and abstract sequence task contributions shift prefrontal cortical connectivity.

Hannah Hyde1, Nicole C R McLaughlin2,3, Sarah L Garnaat4

  • 1Department of Neuroscience, Brown University, 02912.

Biorxiv : the Preprint Server for Biology
|June 4, 2026
PubMed
Summary
This summary is machine-generated.

Neural circuit connectivity differs in obsessive-compulsive disorder (OCD) during abstract sequencing tasks. While the underlying brain circuit architecture is preserved, functional coordination varies between individuals with OCD and healthy controls.

Keywords:
cognitiveconnectivityeffectivefMRIfunctionalprefrontalsequences

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Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Psychiatry

Background:

  • Obsessive-compulsive disorder (OCD) involves repetitive behaviors, but the neural basis of abstract sequencing remains unclear.
  • Previous research identified cortical regions involved in abstract sequencing, with some showing differential activation in OCD.
  • The coordinated function of these regions and their connectivity patterns in OCD are not well understood.

Purpose of the Study:

  • To investigate task-based functional and effective connectivity within a specific cortical circuit during abstract sequencing.
  • To compare circuit connectivity in individuals with OCD versus healthy controls (HCs).
  • To test hypotheses about prefrontal regions directing information flow in this circuit.

Main Methods:

  • Examined functional and effective connectivity using a previously published dataset.
  • Analyzed connectivity among rostrolateral prefrontal cortex (RLPFC), anterior cingulate cortex/dorsolateral prefrontal cortex (ACC/DLPFC), supplementary motor area (SMA), middle temporal gyrus (MTG), and temporo-occipital junction (TOJ).
  • Compared connectivity patterns between individuals with OCD and HCs during an abstract sequencing task.

Main Results:

  • Significant differences in circuit connectivity were observed between OCD and HCs.
  • HCs showed coordinated prefrontal control with stronger RLPFC-DLPFC coupling.
  • OCD group exhibited increased RLPFC-MTG connectivity, suggesting altered information flow.

Conclusions:

  • A shared circuit architecture for abstract sequencing exists in both OCD and HCs.
  • Differences in OCD lie in the functional coordination within this preserved circuit, particularly involving prefrontal regions.
  • Findings contribute to neurobiological models of OCD and identify a circuit critical for abstract sequencing.