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Published on: May 3, 2018
Association of cardio-ankle vascular index value with cardiovascular risk factors in elderly individuals
Jinbo Liu1,2,3, Lin Ma4, Xuechen Cui1
1Department of Vascular Medicine, Peking University Shougang Hospital, Jinyuanzhuang Road 9, Shijingshan District, Beijing 100144, PR China.
Insights
Cardio-ankle vascular index (CAVI) increases with age in the elderly. Factors like blood pressure and diabetes influence CAVI, necessitating age-specific interventions to prevent cardiovascular disease.
Area of Science:
- Gerontology
- Cardiovascular Medicine
- Vascular Health
Background:
- Cardio-ankle vascular index (CAVI) is a key indicator for assessing arteriosclerosis.
- Understanding CAVI changes in the elderly is crucial for preventing cardiovascular and cerebrovascular diseases.
Purpose of the Study:
- To investigate the age-related changes in CAVI among the elderly population.
- To identify factors associated with CAVI variations in different elderly age groups.
Main Methods:
- 1117 elderly subjects were categorized into three age groups (60-69, 70-79, ≥80 years).
- CAVI was measured using the VaseraVS-1000 vascular screening system.
- Statistical analyses, including General Linear Model, were employed to identify associated factors.
Main Results:
- Significant differences in BMI, CAVI, blood pressure, and biochemical markers were observed across age groups.
- CAVI values showed a progressive increase with age, correlating with higher incidences of hypertension, coronary artery disease, and stroke.
- Age, diabetes, BMI, diastolic blood pressure, and HDL-C were identified as independent factors associated with CAVI.
Conclusions:
- CAVI increases with aging, highlighting the progression of arteriosclerosis.
- Intervention strategies for managing CAVI should be tailored to specific age groups, focusing on blood pressure for those 60-69 and diabetes for those 70-79.
- These findings provide a basis for targeted interventions to mitigate arteriosclerosis progression in the elderly.
Background:
Cardio-ankle vascular index (CAVI) is an important indicator to evaluate arteriosclerosis. This study was to explore the changes and related factors of CAVI in the elderly population, providing a certain basis for the prevention and control of cardiovascular and cerebrovascular diseases.
Methods:
1117 subjects (M/F 488/629) were divided into three groups according to age: group 1: subjects with age 60-69 years; group 2: subjects with age 70-79 years; group 3: subjects with age≧80 years. CAVI value was recorded by using the VaseraVS-1000 vascular screening system.
Results:
There were significant differences about body mass index (BMI), CAVI, systolic blood pressure (SBP), diastolic blood pressure(DBP), pulse pressure, creatinine, fasting plasma glucose (FPG), total cholesterol, high-density lipoprotein cholesterol (HDL-C) and uric acid between these three groups. CAVI value was increasing year by year, with the increasing incidence of hypertension, coronary artery disease and stroke. General Linear Model analysis showed that age, incidence of diabetes mellitus, BMI, DBP and HDL-C were independent associating factors of CAVI in elderly subjects (β = 0.048, p < 0.001; β = 0.349, p = 0.012; β = -0.060, p = 0.001; β = 0.023, p = 0.001; β = -0.530, p = 0.020; respectively).
Conclusions:
CAVI was increasing with ageing. The influencing factors of CAVI varied among different age groups. Subjects aged 60-69 were needed to pay close attention to blood pressure and subjects aged 70-79 were needed to focus on diabetes meillitus, providing a theoretical basis for intervening in different targets in different age groups, to reduce or delay the progression of arteriosclerosis.
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