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Electrochemical Steady-State Regulation of Pd0 Enables a Switchable Suzuki-Miyaura Coupling Reaction
Xuhui Zou1,2, Yanhui Shi2,3, Jiafeng Ding2,4
1Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, College of Textile Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Abstract:
Catalyst deactivation via Pd0 oxidation limits Suzuki-Miyaura coupling under aerobic conditions. An electrochemical buffering strategy continuously regenerates Pd0 in a membrane-divided cell, driving PdII/Pd0 equilibrium toward active catalyst. Optimal conditions (40 °C, 0.5 M K2CO3, -0.5 V vs RHE) achieve 99.5% yield with 90% Faradaic efficiency. Spatial separation of cathodic reduction and anodic oxidation confines oxidative species, enabling robust turnover under ambient atmosphere. This electrically regulated platform transforms biaryl synthesis into a scalable, tunable process.
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