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Related Experiment Video

Updated: Jun 5, 2026

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion

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Multimodal Perfusion Assessment in Hemodynamically Unstable Patients: A Concise Definitive Review.

Carlos Sanchez-Escalante¹, Xavier Monnet²

¹Critical Care Medicine, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Critical Care Medicine

|June 4, 2026

Summary

This summary is machine-generated.

Assessing tissue perfusion in unstable patients requires multimodal approaches. Integrating tools like capillary refill time guides physiology-driven monitoring and individualized resuscitation, avoiding reliance on single markers.

Keywords:

capillary refill time circulatory shock hemodynamic monitoring peripheral perfusion tissue perfusion assessment

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Published on: April 7, 2023

Area of Science:

Critical Care Medicine
Physiology
Hemodynamics

Background:

Assessing tissue perfusion is crucial for hemodynamically unstable patients.
Macrocirculatory variable normalization doesn't guarantee organ perfusion restoration.

Purpose of the Study:

Review contemporary multimodal perfusion assessment.
Integrate monitoring tools into a physiology-driven framework.
Guide bedside monitoring escalation.

Main Methods:

Literature review of physiologic and clinical studies.
Analysis of randomized trials, observational studies, and reviews.
Evaluation of monitoring tools (CRT, perfusion indices, lactate, etc.).

Main Results:

Multimodal assessment is an integrated physiologic process.
Capillary refill time serves as a clinical anchor.
Complementary tools refine interpretation when uncertainty exists.

Conclusions:

Interpret perfusion assessment holistically, not by single markers.
Escalate monitoring based on patient risk and uncertainty.
Support individualized, physiology-driven resuscitation.