Related Experiment Video
Updated: Jun 6, 2026
Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers
Published on: May 5, 2016
An ultrasensitive Fiber ring laser platform for detection of trace-level Enrofloxacin with a functionalized
Shuyuan Guo1, Haoming Yan1, Miao Liu1
1School of Physics and Electronic Engineering, Shanxi University, Taiyuan 030006, China; Shanxi Key Laboratory of Wireless Communication and Detection, Shanxi University, Taiyuan 030006, China.
Abstract:
A highly sensitive COF-V@ENR Apt/DA-modified fiber ring laser (CED-FRL) system is developed to detect trace-level enrofloxacin (ENR). The system is constructed by integrating a microfiber coated with a composite film of dopamine (DA), covalent organic framework (COF-V) and enrofloxacin aptamer (ENR Apt) into a fiber ring laser (FRL). This system exhibits a refractive index (RI) sensitivity of 1240.288 nm/RIU and a temperature sensitivity of -0.0379 nm/°C. For ENR detection, it shows a significant response over 0.01-100 nM, with a sensitivity of 8.668 nm/nM in 0.01-0.1 nM and a limit of detection (LOD) of 0.009 nM. This biosensor shows high specificity for ENR and performed reliably in real samples. Furthermore, the Gradient Boosting (GB) model is applied for training and validation of the data, achieving a coefficient of determination (R2) of 0.9970. With high sensitivity, strong specificity and good stability, this system has great potential for food safety and environmental monitoring.
