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Updated: Jun 6, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
09:10

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

Intravenous immunoglobulin enhances intestinal stem cell regeneration to mitigate radiation-induced enteritis via

Jia He1, Tiancheng Chu2, Ping Fu2

  • 1Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, Chengdu 610052, China; Basic Research Innovation Center for Acute Radiation Syndrome, Lab of Radiation Biology, Department of Blood Transfusion, Laboratory Medicine Center, The Second Affiliated Hospital of Army Medical University, Chongqing 400037, China.

Stem Cell Reports
|June 4, 2026
PubMed

Radiation-induced enteritis (RIE), a common adverse effect after radiotherapy for pelvic, abdominal, and retroperitoneal tumors, has no effective treatment. Our previous study showed that intravenous immunoglobulin (IVIg) ameliorated radiation toxicity. Here, we investigated the role of IVIg in enhancing intestinal stem cell (ISC) regeneration to mitigate RIE and its underlying mechanism. In a mouse RIE model, IVIg improved tissue repair, reduced intestinal epithelial apoptosis and pyroptosis, decreased inflammatory factors, enhanced antioxidant capacity, and alleviated DNA damage. Notably, IVIg promoted the proliferation of OLFM4+ and LGR5+ ISCs in crypts and mitigated radiation-induced enteroid damage in vitro. Lineage tracing revealed that IVIg enhanced LGR5+ ISCs and their daughter cell survival. Mechanistically, IVIg promoted β-catenin nuclear translocation, and the β-catenin inhibitor MSAB diminished IVIg's radioprotective effects. Collectively, IVIg combats RIE by enhancing ISC regeneration via β-catenin nuclear translocation, highlighting its potential as an RIE therapeutic candidate.

Keywords:
LGR5OLFM4enteroidsintestinal stem cellsintravenous immunoglobulinradiation-induced enteritisradioprotectiontissue repairβ-catenin

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