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Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...

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Related Experiment Video

Updated: Jun 6, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Exercise and Mind-Body Interventions for Cancer-Related Fatigue: A Network Meta-Analysis With Exploratory Moderator

Jingyi Xie1, Zhide Liang2, Mengyao Li3

  • 1School of Physical Education, Central China Normal University, Wuhan, China.

Complementary Therapies in Medicine
|June 4, 2026
PubMed
Summary
This summary is machine-generated.

Multiple exercise and mind-body interventions show promise for reducing cancer-related fatigue (CRF). Evidence suggests various approaches are effective, but no single modality is clearly superior for managing CRF.

Keywords:
Cancer-related fatiguecomplementary therapiesdose–responseexercise interventionmind-body interventionnetwork meta-analysis

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Related Experiment Videos

Last Updated: Jun 6, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

Area of Science:

  • Integrative oncology
  • Symptom management
  • Rehabilitation science

Background:

  • Cancer-related fatigue (CRF) significantly impacts patient quality of life.
  • Effective management strategies for CRF are crucial for supportive cancer care.

Purpose of the Study:

  • To compare the efficacy of various exercise and mind-body interventions for reducing CRF.
  • To identify moderators influencing treatment effectiveness and explore dose-response relationships.

Main Methods:

  • A systematic review and multilevel network meta-analysis of 205 randomized controlled trials (12,629 participants).
  • Risk of bias and certainty of evidence assessed using RoB 2 and CINeMA.
  • Exploratory analyses included meta-analytic random forest and meta-regression for moderators and dose-response patterns.

Main Results:

  • Low-to-moderate certainty evidence indicates exercise and mind-body interventions reduce CRF compared to controls.
  • Effective interventions include aquatic exercise, relaxation training, dance, Pilates, cycling, and Qigong, with overlapping effect sizes.
  • No single modality demonstrated clear superiority; dose-response analyses did not identify an optimal dose.

Conclusions:

  • Multiple exercise and mind-body interventions can help reduce CRF.
  • Patient-centered care should consider individual preferences, feasibility, and clinical context when selecting interventions.
  • Further research may refine understanding of optimal dosing and personalized application.