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Updated: Jun 6, 2026

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

GPR35 in host-microbe interaction: Mechanisms and translational prospects

Jian Chen1, Xiaoying Cai1, Qingyun Ma1

  • 1State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China; Laboratory of Metabolic Regulation and Drug Target Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.

Trends in Pharmacological Sciences
|June 4, 2026
PubMed

Insights

G protein-coupled receptor 35 (GPR35) is a key target for microbiome therapeutics, influencing host health through metabolic, immune, and neural pathways. Further research into its ligands could unlock new drug discovery avenues.

Area of Science:

  • Host-microbe interactions
  • Pharmacology
  • Drug discovery

Background:

  • Host-microbe interactions are crucial for understanding disease and developing new therapeutics.
  • G protein-coupled receptors (GPCRs) act as sensors at the host-microbe interface.
  • G protein-coupled receptor 35 (GPR35) is an orphan receptor implicated in metabolic, immune, and neural functions.

Purpose of the Study:

  • To review current knowledge on GPR35-mediated host-microbe interactions in health and disease.
  • To highlight the potential of GPR35 as a target for microbiome-based therapeutics.
  • To discuss challenges and propose strategies for GPR35 drug discovery.

Main Methods:

  • Literature review and knowledge update on GPR35 function.
  • Analysis of GPR35's role in host-microbe signaling pathways.
  • Discussion of therapeutic translation strategies.

Main Results:

  • GPR35 plays a significant role in host-microbe interactions across metabolic, immune, and neural systems.
  • Advances in GPR35 pharmacology suggest its potential for microbiome-based therapies.
  • Challenges include identifying relevant endogenous ligands and managing species selectivity and signaling bias.

Conclusions:

  • GPR35 represents a promising target for developing novel microbiome-based therapeutics.
  • Further investigation into GPR35's endogenous ligands is necessary for clinical translation.
  • Strategies are needed to ensure balanced efficacy and safety in GPR35-targeted therapies.
Keywords:
GPCRclinical translationgut microbiotahost–microbe interactionsignaling bias

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