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Published on: August 9, 2024
Development and validation of a nomogram model for predicting bone cement leakage during vertebroplasty
Tangfei Ran1, Guiyong Fan1, Zhen Wang1
1Department of Orthopaedics, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, Jiangsu, 215028, China.
BMC Surgery
|June 4, 2026
Summary
This study developed a nomogram to predict bone cement leakage (BCL) during vertebroplasty. The tool aids surgeons in assessing BCL risk before the procedure, improving patient safety.
Area of Science:
- Orthopedic Surgery
- Medical Imaging
- Biostatistics
Background:
- Vertebroplasty is a common procedure for treating vertebral fractures.
- Bone cement leakage (BCL) is a potential complication during vertebroplasty.
- Accurate preoperative risk assessment for BCL is crucial for patient safety.
Purpose of the Study:
- To develop and validate a nomogram model for predicting the risk of bone cement leakage (BCL) during vertebroplasty.
- To provide a visual tool for preoperative risk assessment and clinical decision-making.
Main Methods:
- Retrospective analysis of patients undergoing vertebroplasty.
- Logistic regression to identify independent risk factors for BCL.
- Nomogram construction and validation using ROC curves, calibration curves, and decision curve analysis.
Main Results:
- Identified bone mineral density, multiple fractures, vertebral cortical disruption, degree of vertebral compression, and bone cement injection volume as independent predictors of BCL.
- The developed nomogram demonstrated good discriminative ability and excellent calibration.
Conclusions:
- The nomogram model shows robust predictive performance for BCL during vertebroplasty.
- This visual tool can aid in individualized preoperative risk assessment, potentially improving clinical decision-making.