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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

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The Clinical Pathway Initiative: Identifying role relevant competencies in genomic pathways.

Lianne Gompertz^1,2, Danielle Bogue¹, Judith Hayward^1,3

¹National Genomics Education Programme, NHSE, Birmingham, UK.

Journal of Genetic Counseling

|June 5, 2026

Summary

This summary is machine-generated.

The Clinical Pathway Initiative (CPI) enhances healthcare workforce confidence in genomic medicine by mapping competencies to clinical pathways. This competency-based framework supports consistent, high-level genomic standards in practice.

Keywords:

clinical pathway competencies genomic mainstreaming

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Area of Science:

Genomic Medicine
Healthcare Workforce Education

Background:

Integrating genomic medicine into healthcare requires a competent and confident workforce.
Existing educational approaches may not adequately address the specific needs of genomic medicine integration.

Purpose of the Study:

To evaluate the usefulness, usability, and acceptability of the Clinical Pathway Initiative (CPI).
To assess the CPI's effectiveness in supporting the healthcare workforce for genomic medicine.

Main Methods:

A process evaluation was conducted using a familial hypercholesterolemia (FH) clinical pathway.
Quantitative data collected via rating scales and modified System Usability Scale (SUS).
Qualitative data gathered through interviews and short-answer survey questions.

Main Results:

System Usability Scale (SUS) scores were 65 for development and 72.5 for implementation (above average).
Participants recognized the CPI's value in supporting workforce competence.
Interviewees praised the CPI's simplicity, transferability, and role in promoting consistent genomic standards.

Conclusions:

The Clinical Pathway Initiative (CPI) is a valuable tool for integrating genomic medicine.
The competency-based framework supports workforce development and consistent genomic standards.
Ongoing refinement and evaluation are supported by positive feedback on the CPI.