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Published on: August 2, 2017
Introducing self-sampling for cervical cancer screening: A regional implementation study in Pirkanmaa, Finland
Saara Kyllönen1,2, Satu Saloranta3, Saara Kares3
1Department of Obstetrics and Gynecology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Acta Obstetricia Et Gynecologica Scandinavica
|June 5, 2026
Summary
Home-based HPV testing through self-sampling is highly acceptable and practical for cervical cancer screening. This approach improves participation and convenience for women, demonstrating feasibility outside major urban centers.
Area of Science:
- Gynecologic Oncology
- Public Health
- Molecular Diagnostics
Background:
- Human papillomavirus (HPV) primary testing is the global standard for cervical cancer screening, facilitating convenient at-home vaginal self-sampling.
- Self-sampling demonstrates comparable performance to clinician-collected samples and can significantly boost screening participation, particularly among underrepresented groups.
- While piloted in Helsinki, the implementation of self-sampling outside the capital region required evaluation for broader applicability.
Purpose of the Study:
- To assess the feasibility and acceptability of an at-home HPV self-sampling program for cervical cancer screening in the Pirkanmaa region of Finland.
- To provide a representative model for implementing self-sampling strategies in areas beyond the primary metropolitan center.
Main Methods:
- The FALCON study offered an opt-in self-sampling option via reminder letters to women in Pirkanmaa who initially missed screening invitations.
- Participants received a kit with a FLOQSwab, instructions, and a prepaid return envelope; samples were analyzed using the Roche Cobas 4800 HPV assay.
- Two online questionnaires captured participant feedback on the self-sampling process and experience.
Main Results:
- Out of 16,289 reminder letters, 329 kits were ordered, with 304 (1.9%) samples returned.
- Key motivators for self-sampling included time-saving, reduced discomfort, and decreased embarrassment.
- HPV was detected in 6.9% of samples, leading to one histological HSIL diagnosis; participants reported high ease of use and comfort, with near-universal recommendation intent.
Conclusions:
- Despite a limited initial participant cohort, the study provides early evidence supporting the high acceptability and practicality of HPV self-sampling in Pirkanmaa.
- The findings suggest that self-sampling is a viable strategy for cervical cancer screening in diverse geographical settings.
- Further large-scale evaluation is warranted to confirm these promising results and optimize implementation.
