Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Avoidance Learning and Learned Helplessness01:14

Avoidance Learning and Learned Helplessness

Avoidance learning and learned helplessness are critical concepts in understanding behavioral responses to negative stimuli.
Avoidance learning occurs when an organism learns that a specific behavior can prevent an unpleasant outcome. For example, a student who receives a bad grade may start studying harder to avoid future poor grades. This behavior persists even when the negative outcome is no longer present. Avoidance learning is powerful because it maintains behavior in the absence of the...
Electrical Synapses01:28

Electrical Synapses

Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distributed control circuits across a brain-and-cord connectome.

Nature·2026
Same author

Apical spectrin organizes cortical actin filament bundles to pattern <i>C. elegans</i> cuticle ridges.

bioRxiv : the preprint server for biology·2026
Same author

The extracellular matrix gene <i>mec-9</i> regulates <i>C. elegans</i> sensory cilia.

bioRxiv : the preprint server for biology·2026
Same author

Intrinsic and non-cell autonomous roles for a neurodevelopmental syndrome-linked transcription factor.

bioRxiv : the preprint server for biology·2026
Same author

Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

From nematode to Nobel: How community-shared resources fueled the rise of <i>Caenorhabditis elegans</i> as a research organism.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices
11:13

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices

Published on: April 5, 2016

Comparative connectomics reveals stage-specific gap junction rewiring that reshapes avoidance behavior.

Daniel T Choe1, David H Hall2, Ken C Q Nguyen2

  • 1Department of Biological Sciences, Seoul National University; Seoul, 08826, Republic of Korea.

Biorxiv : the Preprint Server for Biology
|June 5, 2026
PubMed
Summary
This summary is machine-generated.

Environmental stress reshapes neural circuits for adaptation. In C. elegans, dauer larvae show shorter nociceptive avoidance due to gap junction remodeling, balancing behavioral flexibility and stability for survival.

More Related Videos

Drosophila Passive Avoidance Behavior as a New Paradigm to Study Associative Aversive Learning
06:20

Drosophila Passive Avoidance Behavior as a New Paradigm to Study Associative Aversive Learning

Published on: October 15, 2021

Straightforward Assay for Quantification of Social Avoidance in Drosophila melanogaster
08:08

Straightforward Assay for Quantification of Social Avoidance in Drosophila melanogaster

Published on: December 13, 2014

Related Experiment Videos

Last Updated: Jun 6, 2026

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices
11:13

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices

Published on: April 5, 2016

Drosophila Passive Avoidance Behavior as a New Paradigm to Study Associative Aversive Learning
06:20

Drosophila Passive Avoidance Behavior as a New Paradigm to Study Associative Aversive Learning

Published on: October 15, 2021

Straightforward Assay for Quantification of Social Avoidance in Drosophila melanogaster
08:08

Straightforward Assay for Quantification of Social Avoidance in Drosophila melanogaster

Published on: December 13, 2014

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Behavioral Science

Background:

  • Environmental stress induces neural circuit remodeling, impacting behavior.
  • The dauer larval stage in C. elegans offers a model for studying stress-induced circuit plasticity.

Purpose of the Study:

  • Investigate how dauer-specific neural circuit remodeling affects nociceptive behavior in C. elegans.
  • Understand the mechanisms underlying behavioral adaptation to environmental stress.

Main Methods:

  • Comparative connectomics to analyze neural circuit differences.
  • Calcium imaging to assess neuronal activity dynamics.
  • Genetic manipulation to introduce dauer-specific gap junctions in adult worms.

Main Results:

  • Dauer larvae exhibit significantly shorter avoidance durations compared to adults.
  • Connectomics revealed expanded gap junctions in the dauer nociceptive circuit.
  • Calcium imaging showed faster, more transient neuronal activity in dauers.
  • Synthetic gap junctions in adults mimicked dauer-like neuronal activity and behavior.
  • Avoidance initiation remained consistent across developmental stages despite circuit changes.

Conclusions:

  • Dauer connectome remodeling via gap junctions tunes behavioral persistence for stress survival.
  • Developmental circuit reorganization balances behavioral flexibility and stability.
  • Neural circuit plasticity is crucial for adapting behavior under environmental stress.