Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or playing an...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CA1 Engram Cell Dynamics Before and After Learning.

bioRxiv : the preprint server for biology·2026
Same author

Diurnal rhythms of choice: a novel state-dependent drift diffusion model uncovers time-dependent changes in rat decision making.

Research square·2026
Same author

Diurnal rhythms of choice: a novel state-dependent drift diffusion model uncovers time-dependent changes in rat decision making.

bioRxiv : the preprint server for biology·2026
Same author

Age-dependent glioma progression and functional decline in a syngeneic murine model: Host vulnerabilities and opportunities for targeted intervention.

Neuro-oncology advances·2026
Same author

Reactivation of memory-associated neurons induces downstream suppression of competing neuronal populations.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Erasable hippocampal neural signatures predict memory discrimination.

Cell reports·2025

Related Experiment Video

Updated: Jun 6, 2026

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue
07:14

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Published on: October 21, 2021

Hippocampal astrocytic sequences emerge during learning and memory.

Ryan A Senne1,2,3, Rebecca L Suthard3, Rui Cao4

  • 1Graduate Program for Neuroscience, Boston University, Boston, MA 02215.

Biorxiv : the Preprint Server for Biology
|June 5, 2026
PubMed
Summary

Astrocytes in the dorsal hippocampus exhibit sequential calcium activity, mirroring hippocampal time cells during fear conditioning. This glial cell activity is context-specific, suggesting a role in associative memory.

More Related Videos

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Related Experiment Videos

Last Updated: Jun 6, 2026

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue
07:14

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Published on: October 21, 2021

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Area of Science:

  • Neuroscience
  • Cellular Neuroscience
  • Systems Neuroscience

Background:

  • The dorsal hippocampus is vital for spatial and temporal memory.
  • Pyramidal cells, including hippocampal time cells, are known to encode temporal information.
  • The function of non-neuronal cells, like astrocytes, in memory is less understood.

Purpose of the Study:

  • To investigate the role of dorsal hippocampal CA1 astrocytes in associative memory.
  • To explore astrocytic activity patterns during contextual fear conditioning.

Main Methods:

  • One-photon calcium imaging in freely moving animals.
  • Tracking glial cell populations over multiple days.
  • Utilizing a contextual fear conditioning paradigm.

Main Results:

  • Astrocytes generated time-compressed calcium-event sequences following foot shock, similar to hippocampal time cells.
  • These astrocytic sequences were observed upon re-exposure to the conditioned context, even without shock.
  • Astrocytic activity patterns were context-dependent and associated with behavioral states like freezing.

Conclusions:

  • Dorsal hippocampal astrocytes play a direct role in generating hippocampal representations of associative memory.
  • Astrocytes contribute to the temporal dynamics of associative memory formation.
  • Further research is needed to understand how diverse cell types process temporal features in memory.