Related Experiment Video
Updated: Jun 6, 2026
08:42
Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
The Biliary Multi-Omics Landscape: Integrating Microbiome and Metabolomics in Gallbladder Carcinogenesis
Doutrina Das1, Ruhi Dixit2, Manoj Pandey1,2,3
1Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Journal of Gastroenterology and Hepatology
|June 5, 2026
Summary
Gallbladder cancer (GBC) involves gut microbiome changes and altered bile acids. These multi-omics signatures may aid early GBC diagnosis and targeted treatments.
Area of Science:
- Gastroenterology and Oncology
- Microbiome Research
- Metabolomics
Background:
- Gallbladder cancer (GBC) is aggressive, often diagnosed late.
- Gallstones are a risk factor, but biliary microbiome's role is emerging.
- This review synthesizes multi-omics data on GBC's microbial and metabolic factors.
Purpose of the Study:
- To elucidate the interplay between microbial dysbiosis and metabolomic shifts in GBC.
- To review multi-omics data concerning the gut-bile axis in gallbladder cancer.
- To identify potential diagnostic and therapeutic targets in GBC.
Main Methods:
- Systematic literature search of PubMed (up to January 2026).
- Focus on biliary bacteria, gut-bile axis, and multi-omics markers.
- Narrative synthesis of metagenomic, metaproteomic, and metabolomic studies.
Main Results:
- GBC shows biliary dysbiosis with enriched Enterobacteriaceae, Streptococcus, and Helicobacter.
- Microbial metabolism of bile acids produces deoxycholic acid (DCA), promoting tumor growth.
- Bacterial proteins and horizontal gene transfer may drive GBC oncogenesis.
Conclusions:
- The GBC multi-omics landscape highlights a complex gut-bile axis.
- Integrated microbial and chemical signatures show potential for early GBC diagnosis.
- These findings suggest avenues for precision therapy in gallbladder cancer.
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