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Published on: May 31, 2017
Development of Formula Design Method Based on SYSTCM (SYSTCM-FD) and Its Application to an Immunoenhancing Herbal
Jiaye Tian1, Bin Yu1, Zewen Wang1
1Key Laboratory of TCM-information Engineer of State Administration of TCM, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
A new method, SYSTCM-FD, integrates traditional Chinese medicine (TCM) research with health food development. This approach successfully created an immune-enhancing formula from TCM, validating its practical application for functional foods.
Area of Science:
- Integrative Medicine
- Pharmacology
- Food Science
Background:
- Traditional Chinese Medicine (TCM) and health-functional foods have distinct development frameworks.
- A unified approach is needed to bridge TCM's efficacy focus with health foods' biomarker-driven development.
- Rising demand for TCM-derived health foods necessitates innovative formula design strategies.
Purpose of the Study:
- To develop SYSTCM-FD, a novel formula design method for TCM-based health products.
- To integrate TCM clinical experience with pharmacological research for health function targeting.
- To create a systematic strategy for developing functional health foods derived from TCM.
Main Methods:
- Integrated data on health functions, biomarkers, pharmacology, efficacies, and TCMs using the SYSTCM database and literature mining.
- Employed an exponential distribution to calculate TCM scores for formula generation.
- Validated the method using immune enhancement as a case study, generating candidate TCMs and formulae.
Main Results:
- SYSTCM-FD incorporates data on 24 health functions, 173 biomarkers, 40 pharmacological effects, 18 efficacies, and 167 TCMs.
- Identified nine candidate TCMs and 126 candidate formulae for immune enhancement.
- A lead formula, containing Siraitia grosvenorii, Ligustrum lucidum, Panax ginseng leaves, and Rosa rugosa, demonstrated significant immune-boosting effects in an immunosuppressed mouse model.
Conclusions:
- SYSTCM-FD provides a robust theoretical and practical framework for developing TCM-based functional health foods.
- The method successfully generated and validated an effective immune-enhancing formula.
- This integrated approach facilitates the advancement of TCM-derived health products.
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