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Updated: Jun 7, 2026
![Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F63025.jpg&w=3840&q=50)
Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol
Published on: September 21, 2021
A Stereospecific Synthesis of (2S,3R)-β-Methyltryptophans
Xiaoshen Ma1, Justin A Newman2
1Department of Discovery Chemistry, Merck & Company, Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02215, United States.
None:
The surging demand for novel tryptophan analogues across small-molecule, bioactive peptide, and conjugate therapeutic modalities underscores an unmet synthetic need for efficient access to (2S,3R)-β-methyltryptophans. Herein, we describe a practical and stereospecific synthesis of (2S,3R)-β-methyltryptophans that offers broad functional group compatibility and structural diversity.
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