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Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer Disease ll: Pathophysiology01:23

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Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
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Related Experiment Video

Updated: Jun 7, 2026

Multi-Modal Home Sleep Monitoring in Older Adults
07:40

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

Combating Alzheimer's through sleep and exercise (CASE): A study protocol.

Debbie Chung1, Brittany A Larsen1, Laurent G Garchitorena Gomez1

  • 1Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1120 NW 14th St., Miami, FL, 33136, USA.

Geroscience
|June 5, 2026
PubMed
Summary
This summary is machine-generated.

Improving sleep and physical activity may help prevent dementia, including Alzheimer's disease (AD). This study explored combined sleep and exercise interventions for cognitive and brain health in older adults.

Keywords:
Alzheimer’s diseaseCognitionExerciseHome-based digital healthMild cognitive impairmentSleep

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Last Updated: Jun 7, 2026

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Published on: September 22, 2020

Area of Science:

  • Neuroscience
  • Gerontology
  • Public Health

Background:

  • Dementia, particularly Alzheimer's disease (AD), affects millions globally, necessitating preventive strategies targeting modifiable risk factors.
  • Behavioral interventions like sleep improvement and physical activity show independent benefits for cognition and health, but their combined effects and scalable delivery are underexplored.

Purpose of the Study:

  • To investigate the effects of sleep improvement, physical activity, and combined interventions on cognitive performance and biomarkers of brain and cardiometabolic health.
  • To examine the potential synergistic effects of combined sleep and exercise interventions.
  • To explore the role of light exposure in modulating sleep parameters.

Main Methods:

  • An 8-week, three-arm randomized controlled trial involving 60 adults aged 55-80 with or without mild cognitive impairment.
  • Interventions included exercise-only, sleep-only, or combined sleep-plus-exercise programs, delivered in-person and/or digitally.
  • Cognitive function was assessed using the Digital Neuro-Signature Platform; plasma biomarkers measured cardiometabolic and AD-related neuropathology.

Main Results:

  • This study is hypothesis-generating and exploratory; specific results are pending.
  • The trial aims to gather data on the association between sleep metrics, cognitive performance, and health biomarkers.
  • It will also assess the impact of exercise and combined interventions on these outcomes.

Conclusions:

  • Findings will inform larger trials on scalable, digital interventions for modifiable Alzheimer's disease risk factors.
  • This research could lead to novel, integrated approaches for dementia prevention.
  • The study highlights the potential of combining behavioral strategies for enhanced cognitive and brain health benefits.