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Updated: Jun 7, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Green α,β-C(sp3)-H Difunctionalization of Saturated Cyclic Amines and Ethers through FeCl3-Catalyzed Dehydrogenative
Fangzhi Hu1, Jia-Wei Li1, Lindong Sun1
1College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, Shandong 266109, P. R. China.
Abstract:
The green α,β-C(sp3)-H difunctionalization of saturated cyclic amines and ethers was developed through FeCl3-catalyzed dehydrogenative [4 + 2] cycloaddition under air, enabling the construction of structurally novel spirooxindole scaffolds. This method featured earth-abundant Fe catalysis, benign oxidant (air), along with atom- and step-economical formal triple C(sp3)-H functionalization. Also, the protocol offers operational simplicity, acceptable yields, and good functional group compatibility.
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