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Kidney Disease: Improving Global Outcomes (KDIGO) life cycle of guideline development series: part 4: translating
Laia Oliveras1, Amara Sarwal2, Benjamin Lazarus3
1Department of Nephrology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.
Abstract:
In this part of the Methods Series, we describe how Kidney Disease: Improving Global Outcomes (KDIGO) guidelines move from evidence synthesis to the development of guideline statements using an adapted Grading of Recommendations Assessment, Development and Evaluation (GRADE) evidence-to-decision framework. We outline how KDIGO Work Groups consider benefits and harms, certainty of evidence, values and preferences, resource use and costs, and considerations for implementation when determining the direction and strength of recommendations. We also clarify the differences between recommendations and practice points.
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