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Updated: Jun 8, 2026
Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
Published on: February 9, 2021
Manganese Vacancy-Engineered Prussian Blue Triggers Pyroptosis-Driven Innate Immunity for Second Near-Infrared Region
Xiaorui Wang1, Runtao Li1, Ye Wang1
1State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), School of Physical and Mathematical Sciences, Nanjing Tech University (Nanjing Tech), Nanjing 211816, China.
This study introduces a novel material (CuVMn-PBA) that synergistically activates innate and adaptive immunity for enhanced cancer immunotherapy. It effectively triggers pyroptosis and the cGAS-STING pathway, leading to significant tumor regression and immune memory.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Immunology
Background:
- Cancer immunotherapy aims to leverage innate and adaptive immunity, but co-activation is challenging.
- Developing novel nanomaterials is crucial for advanced cancer treatment strategies.
Purpose of the Study:
- To construct a dual-functional Prussian blue analogue (CuVMn-PBA) for synergistic immune activation in cancer photoimmunotherapy.
- To investigate the material's ability to activate pyroptosis and the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling pathway.
Main Methods:
- Engineered copper-doped manganese vacancy Prussian blue derivative (CuVMn-PBA) with enhanced near-infrared-II (NIR-II) absorption.
- Utilized 1060 nm laser irradiation to induce reactive oxygen species (ROS) generation and trigger pyroptosis.
- Investigated the activation of the cGAS-STING pathway via released mitochondrial DNA and inflammatory factors.
Main Results:
- CuVMn-PBA demonstrated enhanced NIR-II absorption and photocatalytic activity, leading to robust ROS generation.
- ROS-induced pyroptosis released mtDNA, activating the cGAS-STING pathway and boosting anti-tumor immunity.
- Combined therapy with αPD-1 blockade resulted in complete tumor regression, suppressed distant metastasis, and prevented recurrence.
Conclusions:
- CuVMn-PBA serves as an effective dual pyroptosis and cGAS-STING activator for NIR-II photoimmunotherapy.
- The synergistic activation of innate and adaptive immunity offers a promising strategy for overcoming cancer immune evasion.
- This approach establishes long-term antitumor immune memory, highlighting its potential for preventing tumor recurrence.
