Management of multinodular goitre: Significant nodular regression and avoidance of thyroidectomy-a case report

A 31-year-old euthyroid woman presented in OPD for Unani treatment at Ayurvedic and Unani Tibbia College, New Delhi, with bilateral thyroid nodules confirmed on ultrasonography (TIRADS 3 right lobe; TIRADS 4 and TIRADS 5 left lobe; Bethesda grade 2/3) for which thyroidectomy had been informally recommended at a tertiary care referral hospital. Her Mizaj (temperament) was assessed as Safravi. Treatment comprised of Habbe Ayarij, Itrifal Ghudadi with Arqe Kasni, Majun Dabidulward, Naqooh Shahtara, and Habbe Rasaut for 12 months. Serial ultrasonography documented progressive nodular regression. All gastrointestinal and constitutional symptoms resolved within six months. Thyroid function remained normal throughout. Surgery was indefinitely postponed. This case provides preliminary evidence that Unani pharmacotherapy can achieve clinically meaningful nodular regression in MNG, deferring the need for surgical intervention. Prospective controlled trials are warranted to validate these findings.