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Association between timely initial supportive management and short-term outcomes in pediatric febrile seizures: A

Xiaodan Lai1, Xinyu Qiao2, Xinyue Wang1

  • 1Department of Pediatrics, The Affiliated Suzhou Hospital of Nanjing University Medical School, Suzhou 215153, China.

Brain & Development
|June 7, 2026
PubMed

Insights

Rapid supportive care for febrile seizures (FSs) improves outcomes. Delayed intervention in children with FSs is linked to higher seizure recurrence and adverse events, highlighting the need for timely management.

Area of Science:

  • Pediatric Neurology
  • Emergency Medicine
  • Clinical Outcomes Research

Background:

  • Febrile seizures (FSs) are common in children.
  • The impact of initial management timeliness on FS outcomes requires further investigation.

Purpose of the Study:

  • To examine the association between the timeliness of initial supportive management and short-term clinical outcomes in pediatric febrile seizures.

Main Methods:

  • Retrospective cohort study of 260 children hospitalized for FSs.
  • Defined initial response time as seizure recognition to first intervention.
  • Used logistic regression to analyze outcomes including seizure recurrence and adverse events.

Main Results:

  • Delayed intervention correlated with longer initial response times and physical cooling.
  • Higher rates of adverse events, seizure recurrence, and anti-seizure medication use were observed in the delayed group.
  • Prolonged response time, complex FS, and longer seizure duration independently predicted recurrence.

Conclusions:

  • Timeliness of initial supportive management significantly impacts short-term outcomes in pediatric FSs.
  • Prompt intervention is crucial to reduce seizure recurrence and adverse events.
  • Emphasize rapid, standardized initial management for FSs in acute care settings.
Abstract

Keywords:
Febrile seizureInitial response timeInitial supportive managementRecurrenceShort-term clinical outcome

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