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Related Experiment Video

Updated: Jun 9, 2026

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
09:51

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

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Transfer Strategy Minimizing Twin Risk of Double Blastocyst Transfers Based on Prediction Models.

Kazuma Onishi1, Daichi Inoue1, Yuta Kida2

  • 1Asada Ladies Clinic Nagoya Aichi Japan.

Reproductive Medicine and Biology
|June 8, 2026
PubMed
Summary

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This study developed a simulation model to optimize embryo transfer decisions, balancing pregnancy success with minimized twin risks. The model guides personalized strategies for single embryo transfer (SET) versus double embryo transfer (DET).

Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization
  • Biostatistics

Background:

  • Optimizing embryo transfer strategies is crucial in assisted reproductive technology.
  • Balancing high pregnancy rates with the reduction of multiple gestations, particularly twins, remains a clinical challenge.
  • Current decision-making for single embryo transfer (SET) versus double embryo transfer (DET) often lacks individualized risk assessment.

Purpose of the Study:

  • To develop and validate a simulation model for guiding embryo transfer decisions.
  • To minimize the risk of twin pregnancies per transfer while maintaining high treatment efficiency.
  • To provide an individualized approach to SET versus DET selection.

Main Methods:

  • A retrospective observational study analyzed data from SET and DET cycles using frozen blastocysts in hormone replacement therapy.
Keywords:
algorithmdecision curve analysismodelpredictionsimulation

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Related Experiment Videos

Last Updated: Jun 9, 2026

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
09:51

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

Utero-tubal Embryo Transfer and Vasectomy in the Mouse Model
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Utero-tubal Embryo Transfer and Vasectomy in the Mouse Model

Published on: February 28, 2014

Human Blastocyst Biopsy and Vitrification
10:59

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

  • Three generalized estimating equation-based models were developed to predict ongoing pregnancy after SET and DET, and twin pregnancy after DET.
  • A stepwise optimization simulation was created to identify optimal transfer sequences, balancing pregnancy probability and twin risk thresholds.

    • Main Results:

    • The analysis included 5721 DET cycles and 5719 matched SET cycles.
    • Ongoing pregnancy rates were 20.1% for SET and 25.1% for DET, with an ongoing twin pregnancy rate of 5.5% following DET.
    • The developed models showed strong predictive performance (AUC 0.77-0.82), and the simulation demonstrated an optimal individualized SET/DET sequence.

    Conclusions:

    • The developed simulation model effectively supports individualized embryo transfer planning.
    • It provides a tool to balance treatment efficiency with the critical need to reduce twin risks.
    • This approach aids clinicians and patients in making informed decisions regarding embryo transfer strategies.