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Updated: Jun 9, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
2-[(2,5-Di-methyl-phen-yl)amino]-quinoline-3-carb-oxy-lic acid
1School of Chemical Engineering and Pharmacy Wuhan Institute of Technology,Wuhan Hubei 430205 People's Republic of China.
Abstract:
The title compound, C18H16N2O2, was synthesized via a two-step route with the Buchwald-Hartwig cross-coupling reaction. The quinoline ring system and phenyl ring of the mol-ecule are nearly coplanar with a dihedral angle of 6.51 (5)°. In the crystal, adjacent mol-ecules form carb-oxy-lic acid dimers via inter-molecular hydrogen bonding.
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