Related Experiment Video
Updated: Jun 9, 2026

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
High-flow nasal cannula for acute respiratory failure: a bibliometric analysis of current trends and future
Siying Chen1,2, Zixia Wen1, Chenxi Wang1
1The First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, China.
Background:
High-flow nasal cannula (HFNC) oxygen therapy has emerged as a pivotal non-invasive respiratory support modality for acute respiratory failure (ARF), fundamentally transforming critical care practice. Despite substantial growth in HFNC research and clinical significance, no comprehensive bibliometric analysis has systematically examined the knowledge structure, research trends, and emerging frontiers in this rapidly evolving field.
Methods:
A comprehensive bibliometric analysis was conducted using the Web of Science Core Collection (WOSCC), supplemented by PubMed and Scopus for literature retrieval, covering publications from January 2015 to December 2025. Search terms included combinations of "acute respiratory failure," "respiratory failure," "ARF," "high-flow nasal oxygen," "high-flow oxygen," and "HFNC" in titles and abstracts. Data were analyzed using three visualization tools: CiteSpace (version 6.4.R1), VOSviewer (version 1.6.20), and Bibliometrix in R (version 4.5.1) to examine publication trends, country collaborations, author networks, journal distributions, co-citation patterns, and keyword evolution.
Results:
A total of 1,477 publications were identified, with annual output peaking at 256 in 2022, reflecting intensified research during the COVID-19 pandemic. The United States led in productivity (n = 139), while France achieved the highest citation impact (TC = 7,726). Keyword and co-citation clustering revealed evolving research foci from foundational respiratory support (2015-2017) to pandemic-driven applications (2019-2021) and emerging artificial intelligence (AI) integration (2022-2025). Nine distinct research clusters were identified, with recent emphasis on chronic obstructive pulmonary disease, reintubation, and advanced respiratory technologies.
Conclusion:
The findings highlight HFNC's successful transition from experimental therapy to evidence-based standard care, with future trends indicating movement toward personalized medicine approaches and technology-enhanced respiratory care delivery systems.
More Related Videos
Related Concept Videos
Oxygen Delivering System I: Nasal Cannula and Face Mask
Nasal Cannula
A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...
Administering Oxygen by Nasal Cannula
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils, connected...
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Acute Respiratory Failure-I
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Acute Respiratory Failure-III
Respiratory Assessment: Purpose and Indications
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...

