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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

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Published on: February 12, 2017

Pathological Complete Response to Nivolumab Plus Ipilimumab Combination Therapy in Advanced Renal Cell Carcinoma With

Takuto Tsuchiya¹, Go Kimura¹, Hayato Takeda¹

¹Department of Urology Nippon Medical School Tokyo Japan.

IJU Case Reports

|June 8, 2026

Abstract

Introduction:

Nivolumab plus ipilimumab is a standard first-line regimen for advanced renal cell carcinoma; however, primary tumors often respond less favorably to this combination than to immune checkpoint inhibitor-tyrosine kinase inhibitor regimens, and pathological complete response is rare.

Case Presentation:

A 78-year-old man presented with abdominal pain. Computed tomography revealed a 91-mm right renal mass with a Neves level 3 inferior vena cava tumor thrombus. Needle biopsy confirmed clear cell renal cell carcinoma with diffuse programmed death-ligand 1 expression, and both the tumor proportion and combined positive scores were approximately 100%. Nivolumab plus ipilimumab was administered. After 21 months, the primary tumor decreased in size by 68.1% and tumor thrombus regressed from level 3 to 1. Histopathological examination following radical nephrectomy with tumor thrombectomy demonstrated a pathological complete response.

Conclusion:

Diffuse programmed death-ligand 1 expression on pretreatment biopsy may have been associated with a favorable response to nivolumab plus ipilimumab.

Keywords:

inferior vena cava tumor thrombus nivolumab plus ipilimumab pathological complete response programmed death‐ligand 1 expression renal cell carcinoma

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