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Updated: Jun 9, 2026

Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker
Published on: September 15, 2023
ITGA5 is overexpressed and promotes tumor progression through SNAI2 in OSCC
Yanan Li1, Li Kong1, Kai Zhou1
1Biomedical Laboratory, Medical School of Liaocheng University, Liaocheng, China.
None:
Integrin subunit α5 (ITGA5) has been recognized as a potential diagnostic biomarker across multiple cancer types. ITGA5 is upregulated in head and neck squamous cell carcinoma (HNSCC). Oral squamous cell carcinoma (OSCC), with poor prognosis and high mortality, accounts for two-thirds of HNSCC cases. However, the biological functions and underlying mechanisms of ITGA5 in OSCC progression remain unclear. In the present study, we analyzed the expression, prognostic significance, function, and co-expression genes of ITGA5 in HNSCC using a series of public biological information databases, detected the role of ITGA5 in OSCC progression, and discussed the underlying mechanisms. The results indicate that both the mRNA and protein level of ITGA5 were upregulated and related to the prognosis of HNSCC. Knockdown of ITGA5 inhibited cell proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT). However, overexpression of snail family transcriptional repressor 2 (SNAI2) reversed the function of ITGA5 in regulating OSCC cell proliferation, invasion, migration, and EMT. In conclusion, our study suggests that ITGA5 is upregulated in HNSCC and associated with poor prognosis; functional studies indicate ITGA5 promotes OSCC proliferation and metastasis via SNAI2, indicating that ITGA5 may be a potential therapeutic target for OSCC.
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