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A Microparticle Sunscreen with Highly Effective ROS Scavenging and Nonpenetration
Shiliu Zhou1, Shenglei Hou2, Qinghua Lu1
1School of Chemistry and Chemical Engineering, The State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China.
Polymer Science & Technology (Washington, D.C.)
|June 8, 2026
Summary
New self-framed microparticles (SFMPs) offer enhanced sun protection by preventing UV irradiation and reducing skin penetration. These novel microparticles demonstrate strong reactive oxygen species (ROS) scavenging ability without toxicity, promising safer sunscreen applications.
Area of Science:
- Materials Science
- Nanotechnology
- Dermatology
Background:
- Overexposure to ultraviolet (UV) radiation poses health risks.
- Commercial sunscreens face scrutiny regarding safety and efficacy of UV filters.
- UV filter exposure can lead to skin penetration, cytotoxicity, and reactive oxygen species (ROS) production.
Purpose of the Study:
- To develop novel organic UV-filter self-framed microparticles (SFMPs).
- To enhance UV protection while minimizing health risks associated with UV filters.
- To improve the stability and delivery of UV filters and antioxidants.
Main Methods:
- One-pot precipitation polycondensation to self-assemble UV filters, antioxidants, and hexachlorocyclotriphosphazene into microparticles.
- Evaluation of UV-shielding performance in vitro and in vivo.
- Assessment of skin penetration, ROS scavenging ability, and cytotoxicity.
Main Results:
- SFMPs effectively prevent UV irradiation and possess strong ROS scavenging capabilities.
- Skin penetration of UV filters was significantly reduced.
- SFMP microparticles demonstrated excellent UV protection in vitro and in vivo with no observed toxicity.
- Incorporation into microparticles resolved issues of antioxidant instability and UV filter solubility/aggregation.
Conclusions:
- SFMPs offer a promising approach to safer and more effective sunscreens.
- The developed microparticles provide superior UV protection and ROS scavenging.
- SFMPs minimize direct skin contact with UV filters, reducing potential health risks.
