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Depigmentation Outcomes in Pigmented Oral Lichen Planus Managed With Mycophenolate Mofetil
Tania Biswas1, Atul Anand Bajoria1, Noureen Nahar1
1Department of Oral Medicine and Radiology Kalinga Institute of Dental Sciences Bhubaneswar Odisha India.
Clinical Case Reports
|June 8, 2026
Summary
Pigmented oral lichen planus, a condition causing dark mouth discoloration, can be effectively treated with mycophenolate mofetil (MMF). This treatment offers relief from symptoms and reduces hyperpigmentation in challenging cases.
Area of Science:
- Oral Medicine
- Dermatology
- Immunology
Background:
- Pigmented oral lichen planus (OLP) presents as a chronic, immune-mediated condition.
- Characterized by dark melanin deposition causing black/brown discoloration.
- Often co-occurs with reticular or erosive OLP and resists standard treatments.
Purpose of the Study:
- To report a successful management of pigmented OLP.
- To evaluate the efficacy of oral mycophenolate mofetil (MMF).
Main Methods:
- A case study of a patient with persistent pigmented OLP.
- Treatment administered with oral mycophenolate mofetil (MMF).
Main Results:
- Significant symptomatic relief was achieved.
- Reduction in oral hyperpigmentation observed.
- MMF demonstrated effectiveness in managing the condition.
Conclusions:
- Oral mycophenolate mofetil (MMF) is a safe and effective systemic therapy.
- MMF provides a viable option for persistent pigmented OLP.
- Successful management of refractory OLP cases is possible.
