Y-90 Radioembolization Through Aberrant Arterial Supply: Four-Case Experience

Area of Science:

• Interventional Radiology
• Hepatobiliary Oncology
• Vascular Imaging

Background:

• Hepatic vascular anatomy frequently exhibits variations.
• Limited data exists on Y-90 radioembolization (RE) through nonhepatic arterial feeders.
• Aberrant tumor vascularization can complicate RE, sometimes leading to TACE or treatment abandonment.

Purpose of the Study:

• To evaluate the safety and efficacy of Y-90 RE using aberrant arterial feeders in liver lesions.
• To assess the feasibility of RE in tumors with non-standard hepatic vascular supply.
• To highlight the importance of recognizing and managing extrahepatic arterial feeders.

Main Methods:

• Retrospective case series analysis of patients undergoing Y-90 RE.
• Identification and selective catheterization of aberrant hepatic and extrahepatic arterial feeders.
• Careful procedural planning to prevent extrahepatic radioactive microsphere leakage.
• Assessment of treatment response and complications.

Main Results:

• Y-90 RE was successfully and safely performed using aberrant feeders in selected patients.
• Effective tumor treatment was achieved without significant extrahepatic leakage.
• This approach offers an alternative for patients with complex hepatic vascular anatomy.

Conclusions:

• Y-90 radioembolization is a viable and effective treatment option for liver tumors with aberrant vascularization when using nonhepatic feeders.
• Meticulous attention to preventing extrahepatic leakage is crucial for successful outcomes.
• This technique expands treatment possibilities for complex hepatobiliary malignancies.