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Systemic Immune-Inflammation Index as a Prognostic Marker in Mycosis Fungoides
Gökçe Işıl Kurmuş1, Dilek Menteşoğlu2, Selda Pelin Kartal2
1Department of Dermatology and Venereology, Ankara Etlik City Hospital, Ankara, Turkey isilkurmus@gmail.com.
Annals of Clinical and Laboratory Science
|June 8, 2026
Summary
The systemic immune-inflammation index (SII) can predict advanced-stage mycosis fungoides (MF). Elevated SII levels are linked to more severe MF, making it a useful prognostic marker.
Area of Science:
- Oncology
- Dermatology
- Immunology
Background:
- Systemic immune-inflammation index (SII) is a known prognostic factor in various cancers.
- While systemic inflammation in mycosis fungoides (MF) is studied, the prognostic role of SII in MF is not well-defined.
Purpose of the Study:
- To investigate the association between SII and disease stage in MF patients.
- To determine if elevated SII values correlate with advanced-stage MF.
Main Methods:
- Retrospective analysis of 126 MF patients.
- Evaluated SII alongside other inflammatory markers and clinicopathological variables.
- Assessed prognostic utility using receiver operating characteristic (ROC) curve analysis.
Main Results:
- SII demonstrated the highest area under the curve (AUC) for distinguishing MF patients from controls (AUC=0.828).
- SII showed significant diagnostic accuracy in differentiating early from advanced MF stages (AUC=0.891, p<0.001).
- Optimal cut-off values were identified for both MF patient identification and stage differentiation.
Conclusions:
- The systemic immune-inflammation index (SII) is a valuable, cost-effective prognostic marker for advanced-stage MF.
- Elevated SII can help identify high-risk MF patients requiring closer monitoring or early intervention.
