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Systemic Immune-Inflammation Index as a Prognostic Marker in Mycosis Fungoides
Gökçe Işıl Kurmuş1, Dilek Menteşoğlu2, Selda Pelin Kartal2
1Department of Dermatology and Venereology, Ankara Etlik City Hospital, Ankara, Turkey isilkurmus@gmail.com.
Objective:
The systemic immune-inflammation index (SII) is considered a prognostic factor in numerous malignancies and is associated with disease progression. Although systemic inflammation has been investigated in mycosis fungoides (MF), the prognostic significance of SII remains unclear. This study aimed to evaluate the association between SII and disease stage in MF and to determine whether elevated SII values are related to advanced-stage disease.
Methods:
A retrospective analysis was performed on 126 patients diagnosed with MF at a tertiary center. The prognostic utility of SII was assessed alongside neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and clinicopathological variables including age, sex, disease stage, lactate dehydrogenase, and beta-2 microglobulin levels.
Results:
Receiver operating characteristic curve analysis demonstrated that SII had the highest area under the curve (AUC) among the evaluated markers. For distinguishing MF patients from controls, SII yielded an AUC of 0.828 at a cut-off value >410.61 (sensitivity 70.63%, specificity 84.40%). In differentiating early and advanced MF stages, SII showed the highest diagnostic accuracy (AUC 0.891, p<0.001; sensitivity 80.95%, specificity 88.57%) with an optimal cut-off value of 891.02.
Conclusions:
SII is a cost-effective and accessible prognostic marker for advanced-stage MF and may aid in identifying high-risk patients who benefit from closer monitoring or earlier intervention.
