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Preventing GLP-1-Associated Facial Aging: An Anatomy-Driven Risk Stratification Model and Prevention Algorithm in the
Ricardo Castrellon1, Karla Maita2, Emily Witt3
1Department of Plastic & Reconstructive Surgery, Larkin Community Hospital, Palm Spring Campus, 1475 W 49th Pl, Hialeah, FL, 33012, USA. researchrcastrellon@gmail.com.
Background:
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have transformed metabolic care but are increasingly associated with rapid, region-specific facial volume loss, commonly referred to as "Ozempic face." Current literature remains descriptive and largely focused on late-stage correction.
Objective:
To propose a conceptual, anatomy-driven framework for early identification and prevention of GLP-1 RAs-associated facial aging.
Methods:
This manuscript presents a hypothesis-generating model developed through integration of facial aging biomechanics, emerging literature on GLP-1 RAs-associated changes, and clinical pattern recognition.
Results:
We introduce a risk-stratification model based on anatomical phenotype and a four-phase conceptual prevention algorithm aligned with weight-loss kinetics. The framework incorporates early intervention strategies, clinical "off-ramps," and patient-specific modifiers to guide anticipatory management.
Conclusion:
This conceptual model proposes a shift from reactive correction to preventive, anatomy-based management of GLP-1 RAs-associated facial changes. Future studies are needed to validate and refine this framework.
Level Of Evidence V:
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
