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Liquid Biopsy Biomarkers as Predictors of TNBC Recurrence: A Systematic Review
Nur Rahadiani1, Dyah Laksmi Dewi2, Mohammad Ghozali3
1Department of Anatomical Pathology, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Introduction:
Triple-negative breast cancer (TNBC) is associated with high recurrence and mortality. Liquid biopsy biomarkers, such as circulating tumor DNA (ctDNA), cell-free DNA (cfDNA), and microRNAs (miRNAs), offer noninvasive tools for monitoring TNBC.
Methods:
A systematic review on liquid biopsy in TNBC was conducted and analyzed using PRISMA guidelines and later assessed via the EPHPP tool.
Results:
Across 20 studies, ctDNA was a strong predictor for poorer disease-free survival (DFS) and relapse-free survival (RFS). Other biomarkers, including cfDNA and miRNAs, also showed prognostic value.
Conclusion:
Liquid biopsy, particularly ctDNA, is a valuable predictor of TNBC recurrence, supporting noninvasive monitoring and prognosis.
