Rapid Hemostasis and Antiadhesion Gauze Based on a Structured Hydrophobic Surface Engineered by an Inorganic LDH...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Trauma Medicine

Background:

• Uncontrolled hemorrhage is a leading cause of trauma mortality.
• Conventional gauze has limitations in achieving rapid hemostasis and preventing tissue adhesion.

Purpose of the Study:

• To develop and evaluate Gauze@LDH, a novel hemostatic gauze engineered with layered double hydroxide nanosheets.
• To assess the hemostatic efficacy, biocompatibility, and anti-adhesion properties of Gauze@LDH.

Main Methods:

• Gauze modification using magnesium/aluminum layered double hydroxide nanosheets via hydrothermal synthesis.
• Evaluation of surface properties, blood absorption, clotting time, biocompatibility (hemolysis, cytotoxicity), and hemostatic performance in simulated and in vivo trauma models.

Main Results:

• Gauze@LDH demonstrated a shift from hydrophilic to hydrophobic, reducing blood absorption.
• Achieved rapid clotting in 1 minute, three times faster than conventional gauze.
• Showcased excellent biocompatibility with low hemolysis (0.209%) and minimal cytotoxicity.
• Significantly reduced blood loss in simulated vascular rupture models.
• Confirmed immediate hemostatic efficacy in vivo liver defect and tail-vein transection models.
• Prevented organ adhesions in a liver-penetrating injury model, unlike plain gauze.

Conclusions:

• Gauze@LDH integrates rapid hemostasis, biocompatibility, and anti-adhesion properties.
• This engineered gauze addresses key limitations of current hemostatic agents.
• Gauze@LDH presents a cost-effective solution for improving trauma care outcomes.