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Related Experiment Video

Updated: Jun 10, 2026

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment
10:33

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment

Published on: April 25, 2025

⁶⁸Ga-FAPI PET/CT Unmasks Extensive Metastatic Invasive Lobular Breast Cancer when Conventional Imaging Falls Short.

Sharjeel Usmani1, Khulood Al Riyami1, Anjali Jain1

  • 1Department of Radiology and Nuclear Medicine, Sultan Qaboos comprehensive cancer care and research center (SQCCCRC), Muscat Oman.

JPMA. the Journal of the Pakistan Medical Association
|June 9, 2026
PubMed
Summary
This summary is machine-generated.

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A Curious "Mickey Mouse" Sign: Physiological FAPI Uptake in Uterus Didelphys on 68Ga-FAPI PET/CT.

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Nonuniformity in a Certified <sup>68</sup>Ge PET Cylinder Phantom: Implications for Normalization Quality Assurance.

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Impact of Point-Spread Function Modeling on Image Quality in <sup>68</sup>Ga-PSMA PET/CT.

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Integration of ⁶⁸Ga-DOTA-TOC PET/CT into radiotherapy planning for intracranial meningiomas: A precision-imaging approach to tumor delineation.

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The Alien Antenna Sign: Physiological ⁶⁸Ga-FAPI Uptake in the Round Ligament.

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68Ga-DOTATOC PET/CT in the Evaluation of Carney Triad Spectrum Tumors With an Associated Adrenal Adenoma.

Clinical nuclear medicine·2026

Invasive lobular carcinoma (ILC) is challenging to diagnose with standard imaging. Whole-body ⁶⁸Ga-FAPI PET/CT offers superior detection of ILC extent compared to conventional methods.

Area of Science:

  • Oncology
  • Radiology
  • Nuclear Medicine

Background:

  • Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
  • ILC presents diagnostic challenges for conventional imaging modalities like mammography, ultrasound, and MRI.
  • Accurate staging is crucial for effective treatment planning in ILC.

Purpose of the Study:

  • To evaluate the diagnostic utility of whole-body ⁶⁸Ga-FAPI PET/CT in a case of invasive lobular carcinoma.
  • To compare the disease burden detected by ⁶⁸Ga-FAPI PET/CT with conventional imaging techniques.
  • To highlight the potential of ⁶⁸Ga-FAPI PET/CT in improving the assessment of ILC extent.

Main Methods:

  • Case report of a 39-year-old female with newly diagnosed invasive lobular carcinoma.
Keywords:
Lobular breast cancer; 68Ga-FAPI PET/CT; Fibroblast activation protein; cancer-associated fibroblasts; FAPI PET/CT; breast cancer

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Last Updated: Jun 10, 2026

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Published on: April 25, 2025

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  • Standard breast imaging including mammography was performed.
  • Conventional bone scintigraphy was used to assess for skeletal metastases.
  • Whole-body ⁶⁸Ga-FAPI PET/CT was utilized for comprehensive disease staging.

    • Main Results:

    • Mammography showed a single irregular mass in the left breast.
    • Conventional bone scintigraphy did not reveal any skeletal metastases.
    • Whole-body ⁶⁸Ga-FAPI PET/CT demonstrated a significantly different and potentially larger disease burden than initially suggested.
    • This indicates limitations of conventional imaging in fully characterizing ILC extent.

    Conclusions:

    • Whole-body ⁶⁸Ga-FAPI PET/CT provides critical additional diagnostic information in invasive lobular carcinoma.
    • This advanced imaging technique can reveal the true extent of ILC, especially when conventional methods are limited.
    • ⁶⁸Ga-FAPI PET/CT may improve the accuracy of staging and guide treatment decisions for ILC patients.