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Nonuniformity in a Certified 68Ge PET Cylinder Phantom: Implications for Normalization Quality Assurance
Subhash Kheruka1, Sana Al-Rashdi2, Naema Al-Maymani2
1Department of Radiology & Nuclear Medicine, Sultan Qaboos Comprehensive Cancer Care and Research Centre, University Medical City, Muscat, Oman skheruka@gmail.com.
A manufacturing defect in a certified Germanium-68 (68Ge) PET phantom caused a hot spot, exceeding uniformity limits. This highlights the need for independent testing of PET phantoms to ensure accurate quantitative imaging.
Area of Science:
- Medical Imaging
- Nuclear Medicine
- Radiochemistry
Background:
- Accurate quantitative Positron Emission Tomography (PET) imaging relies on precise system normalization and uniformity calibration.
- Certified Germanium-68 (68Ge) PET cylinder phantoms are essential tools for quality control in scanners like the Siemens Biograph Vision.
Purpose of the Study:
- To report a manufacturing defect in a certified 68Ge PET phantom.
- To assess the impact of the defect on quantitative PET imaging accuracy.
Main Methods:
- Utilized a certified RadQual 68Ge PET cylinder phantom (BMCY68-2030A-03) for system normalization and uniformity calibration.
- Identified a localized hot spot within the phantom material.
Main Results:
- The identified hot spot resulted in an integral uniformity exceeding 8.5%, significantly above the acceptance limit of ≤5%.
- The observed nonuniformity was intrinsic to the phantom material, rendering it unsuitable for quantitative PET applications.
Conclusions:
- Independent acceptance testing of long-lived 68Ge standards is crucial before clinical use.
- Failure to detect such defects can lead to calibration bias and compromise the reliability of Standardized Uptake Value (SUV) quantification in PET imaging.
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